Brain structure and function | WP3
Understanding sex-dependent differences in autism at an organ-level, in this case the brain, is essential to address the knowledge gap in the biological mechanisms underlying sex differences in autistic traits. Here, we hypothesise that the structural and functional brain changes in people diagnosed with autism are different for males and females. We will use advanced Magnetic Resonance Imaging methods in humans and mouse models, profiting from both large-n power and high precision, high-field scanning to characterise the sex- dependent brain differences in humans and mouse model systems. Understanding the morphological features associated with sex differences will allow for the development of better diagnostic tools, and a better understanding and possibly improved societal perception of autism.
Involved partners
Erasmus MC, VU Amsterdam, University of Twente, NTR, NAR, GenR, Philips MR, Arivis and Sophia Foundation
“Determine brain features that co-segregate with sex in autism”